Research paper on acute radiation syndrome

research paper on acute radiation syndrome

consistent with the known systemic inflammatory response resulting from exposure to WBI. Dörr., Meineke. Since the number of radiation-exposed patients treated with hematopoietic factors is limited and randomized controlled clinical trials cannot be performed after radiation accidents, the main supporting evidence for the effectiveness of hematopoietic factors in ARS is based on experimental animal studies 20, 25,. While there are species specific differences in miRNA expression profiles, on the whole, there is a strong correlation in miRNA ARS biomarkers identified in this study and others reported in literature involving murine models.

research paper on acute radiation syndrome

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From past experiences, we know that radiation accidents fortunately are rare events; therefore, the number of patients suffering from acute radiation effects and ARS is limited. Like in rodents, circulating miR-150-5p was identified as the most sensitive biomarker for radiation biodosimetry. Exposure to research paper compare and contrast WBI doses 2 Gy could lead to ARS. Changes in miRNA abundance in irradiated animals were compared to a non-irradiated cohort and a cohort experiencing acute inflammation response from exposure to lipopolysaccharide (LPS). Where the average log2 count did not exceed the measured limit of detection for the platform, determined by the average log2 counts of internal negative controls plus three times the standard deviation, was removed from subsequent analysis. After lysis, three synthetic oligonucleotides (spike-in oligos) were added. For example, evolutionarily conserved sequences such as miR-451 and miR-150 are highly expressed in bone marrow 15, regulating hematopoiesis, and miR-126 and let-7 family members show high expression in lung 16,. Time course of blood (A) lymphocyte and (B) neutrophil depression after graded doses of WBI in NHPs. Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression. Circulating microRNAs as stable blood-based markers for cancer detection. Hhso C the National Institute of Allergies and Infectious Disease (niaid; Grant 1R43AI A1 the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program (Award. The data from this study could be used to develop a multi-marker panel with known tissue-specific origin that could be used for developing rapid assays for dose assessment and evaluation of radiation injury on multiple organs.

The purpose of this paper is to describe the underlying pathologic. Herein, we report that aimp3, a previously demonstrated tumour suppr essor. Acute radiation syndrome (ARS) is caused by excessive exposure.

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